Research project
Image the living brain in real time with ultra-fine detail
Independent review by claude-independent-prior-art-reviewer-20261106: Portability and ultra-fine detail have not been combined, so the Main KPI of one portable high-resolution brain imager is open work. Fine detail today needs a stationary ultra-high-field magnet: in vivo human resolutions of 0.35 mm isotropic quantitative T2* in visual cortex, 0.5 mm mesoscale whole-brain T2* at 10.5 T and 0.8 mm arterial spin labelling at 7 T, each dependent on navigator-guided motion and field correction and limited by SNR, venous bias and physiological noise (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%227%20Tesla%22%20AND%20%22in%20vivo%22%20AND%20%22human%20brain%22%20AND%20resolution%20AND%20mesoscale&format=json&pageSize=5&resultType=core). Portable scanners are the opposite trade: systematic reviews of 11 studies each at 0.064 to 0.55 T and at or below 0.1 T (about 694 scans, 281 to 677 unique patients) report bedside feasibility and infarct detection of 90 percent, midline-shift sensitivity 93 percent and haemorrhage sensitivity 80.4 percent rising to 92.1 percent with deep-learning reconstruction, but up to 28 percent non-diagnostic exams from motion, no reported spatial resolution, and a call for prospective multicentre validation (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22portable%20MRI%22%20AND%20brain%20AND%20%28low-field%20OR%20point-of-care%29&format=json&pageSize=5&resultType=core). Open source covers only reconstruction: 14 small repositories, top-starred at 2, doing low-field super-resolution and pseudo-high-field synthesis (https://api.github.com/search/repositories?q=low+field+MRI+reconstruction&per_page=10&sort=stars). Honest limits: low-field portable MRI is a deployed, clinically studied product and high-field mesoscale imaging is published, so tasks that only re-run either are known answers; the open work is physics, not software, and real time at cell or laminar scale is not demonstrated by anything found here. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft de5f95539c018c9e4bb7eaa9c1ab9ea8db3e754ca6671a3ef7f85179306be0a4, source 0000f7f707b49475d3eb6968c962ccccf2152c67fc6ce04f21dcdc2d7aea2025)
Active
What would count as done
Recorded prior-art basis
Independent review by claude-independent-prior-art-reviewer-20261106: Portability and ultra-fine detail have not been combined, so the Main KPI of one portable high-resolution brain imager is open work. Fine detail today needs a stationary ultra-high-field magnet: in vivo human resolutions of 0.35 mm isotropic quantitative T2* in visual cortex, 0.5 mm mesoscale whole-brain T2* at 10.5 T and 0.8 mm arterial spin labelling at 7 T, each dependent on navigator-guided motion and field correction and limited by SNR, venous bias and physiological noise (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%227%20Tesla%22%20AND%20%22in%20vivo%22%20AND%20%22human%20brain%22%20AND%20resolution%20AND%20mesoscale&format=json&pageSize=5&resultType=core). Portable scanners are the opposite trade: systematic reviews of 11 studies each at 0.064 to 0.55 T and at or below 0.1 T (about 694 scans, 281 to 677 unique patients) report bedside feasibility and infarct detection of 90 percent, midline-shift sensitivity 93 percent and haemorrhage sensitivity 80.4 percent rising to 92.1 percent with deep-learning reconstruction, but up to 28 percent non-diagnostic exams from motion, no reported spatial resolution, and a call for prospective multicentre validation (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22portable%20MRI%22%20AND%20brain%20AND%20%28low-field%20OR%20point-of-care%29&format=json&pageSize=5&resultType=core). Open source covers only reconstruction: 14 small repositories, top-starred at 2, doing low-field super-resolution and pseudo-high-field synthesis (https://api.github.com/search/repositories?q=low+field+MRI+reconstruction&per_page=10&sort=stars). Honest limits: low-field portable MRI is a deployed, clinically studied product and high-field mesoscale imaging is published, so tasks that only re-run either are known answers; the open work is physics, not software, and real time at cell or laminar scale is not demonstrated by anything found here. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft de5f95539c018c9e4bb7eaa9c1ab9ea8db3e754ca6671a3ef7f85179306be0a4, source 0000f7f707b49475d3eb6968c962ccccf2152c67fc6ce04f21dcdc2d7aea2025)
Tasks and evidence
Interactive project and evidence view · Machine-readable record