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  "id": "P-OPP-00488",
  "title": "Image the living brain in real time with ultra-fine detail",
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  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: Portability and ultra-fine detail have not been combined, so the Main KPI of one portable high-resolution brain imager is open work. Fine detail today needs a stationary ultra-high-field magnet: in vivo human resolutions of 0.35 mm isotropic quantitative T2* in visual cortex, 0.5 mm mesoscale whole-brain T2* at 10.5 T and 0.8 mm arterial spin labelling at 7 T, each dependent on navigator-guided motion and field correction and limited by SNR, venous bias and physiological noise (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%227%20Tesla%22%20AND%20%22in%20vivo%22%20AND%20%22human%20brain%22%20AND%20resolution%20AND%20mesoscale&format=json&pageSize=5&resultType=core). Portable scanners are the opposite trade: systematic reviews of 11 studies each at 0.064 to 0.55 T and at or below 0.1 T (about 694 scans, 281 to 677 unique patients) report bedside feasibility and infarct detection of 90 percent, midline-shift sensitivity 93 percent and haemorrhage sensitivity 80.4 percent rising to 92.1 percent with deep-learning reconstruction, but up to 28 percent non-diagnostic exams from motion, no reported spatial resolution, and a call for prospective multicentre validation (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22portable%20MRI%22%20AND%20brain%20AND%20%28low-field%20OR%20point-of-care%29&format=json&pageSize=5&resultType=core). Open source covers only reconstruction: 14 small repositories, top-starred at 2, doing low-field super-resolution and pseudo-high-field synthesis (https://api.github.com/search/repositories?q=low+field+MRI+reconstruction&per_page=10&sort=stars). Honest limits: low-field portable MRI is a deployed, clinically studied product and high-field mesoscale imaging is published, so tasks that only re-run either are known answers; the open work is physics, not software, and real time at cell or laminar scale is not demonstrated by anything found here. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft de5f95539c018c9e4bb7eaa9c1ab9ea8db3e754ca6671a3ef7f85179306be0a4, source 0000f7f707b49475d3eb6968c962ccccf2152c67fc6ce04f21dcdc2d7aea2025)",
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    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: Portability and ultra-fine detail have not been combined, so the Main KPI of one portable high-resolution brain imager is open work. Fine detail today needs a stationary ultra-high-field magnet: in vivo human resolutions of 0.35 mm isotropic quantitative T2* in visual cortex, 0.5 mm mesoscale whole-brain T2* at 10.5 T and 0.8 mm arterial spin labelling at 7 T, each dependent on navigator-guided motion and field correction and limited by SNR, venous bias and physiological noise (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%227%20Tesla%22%20AND%20%22in%20vivo%22%20AND%20%22human%20brain%22%20AND%20resolution%20AND%20mesoscale&format=json&pageSize=5&resultType=core). Portable scanners are the opposite trade: systematic reviews of 11 studies each at 0.064 to 0.55 T and at or below 0.1 T (about 694 scans, 281 to 677 unique patients) report bedside feasibility and infarct detection of 90 percent, midline-shift sensitivity 93 percent and haemorrhage sensitivity 80.4 percent rising to 92.1 percent with deep-learning reconstruction, but up to 28 percent non-diagnostic exams from motion, no reported spatial resolution, and a call for prospective multicentre validation (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22portable%20MRI%22%20AND%20brain%20AND%20%28low-field%20OR%20point-of-care%29&format=json&pageSize=5&resultType=core). Open source covers only reconstruction: 14 small repositories, top-starred at 2, doing low-field super-resolution and pseudo-high-field synthesis (https://api.github.com/search/repositories?q=low+field+MRI+reconstruction&per_page=10&sort=stars). Honest limits: low-field portable MRI is a deployed, clinically studied product and high-field mesoscale imaging is published, so tasks that only re-run either are known answers; the open work is physics, not software, and real time at cell or laminar scale is not demonstrated by anything found here. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft de5f95539c018c9e4bb7eaa9c1ab9ea8db3e754ca6671a3ef7f85179306be0a4, source 0000f7f707b49475d3eb6968c962ccccf2152c67fc6ce04f21dcdc2d7aea2025)",
    "searches": [
      "api.github.com/search/repositories \"image living brain real time ultra-fine\" url=https://api.github.com/search/repositories?q=image%20living%20brain%20real%20time%20ultra-fine&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"image living brain real time ultra-fine\" url=https://export.arxiv.org/api/query?search_query=all%3Aimage%20AND%20all%3Aliving%20AND%20all%3Abrain%20AND%20all%3Areal%20AND%20all%3Atime%20AND%20all%3Aultra-fine&start=0&max_results=10 sha256=df298f86c4542ab205ff78340d66ec6b7b94151939f15960e966291de260d928",
      "api.crossref.org/works \"image living brain real time ultra-fine\" url=https://api.crossref.org/works?query=image%20living%20brain%20real%20time%20ultra-fine&rows=10&select=DOI,title sha256=a081cea143e520a35507fabe4ae48f563fe2403bf7ddf4c72b62d6cb1eb8b2f7",
      "api.github.com/search/repositories \"image living brain neuroscience mental health\" url=https://api.github.com/search/repositories?q=image%20living%20brain%20neuroscience%20mental%20health&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"image living brain neuroscience mental health\" url=https://export.arxiv.org/api/query?search_query=all%3Aimage%20AND%20all%3Aliving%20AND%20all%3Abrain%20AND%20all%3Aneuroscience%20AND%20all%3Amental%20AND%20all%3Ahealth&start=0&max_results=10 sha256=bef8fb88a3e55398336243f5e5044a5172d3fefd89ca45ced3859c934f49b52a",
      "api.crossref.org/works \"image living brain neuroscience mental health\" url=https://api.crossref.org/works?query=image%20living%20brain%20neuroscience%20mental%20health&rows=10&select=DOI,title sha256=07f6890df45174792045f3000bc986a9956f426dbdb2d1f399739765b0d46ce7"
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