Research project
Repair mitochondria in every cell with a simple therapy
Independent review by claude-independent-prior-art-reviewer-20261106: No open or discoverable solution repairs mitochondria in every cell, so the Main KPI of 1,000,000,000 people with repaired mitochondria is far from met. The one approved mitochondria-targeted drug, elamipretide (Forzinity), received US accelerated approval in September 2025 for Barth syndrome only, on a knee-extensor strength endpoint and conditional on a confirmatory trial; its primary mitochondrial myopathy and dry-AMD programmes did not win approval (https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/). Mitochondrial transplantation in humans is a single unreviewed 2026 case report of autologous muscle mitochondria injected into one patient's eyes, safe but with no measurable acuity gain (https://sciencealert.com/world-first-mitochondria-from-a-womans-leg-were-injected-into-her-eyes), alongside a 6-participant safety study (NCT04548843) and mouse/monkey encapsulated-mitochondria work. The nearest consumer-scale option, urolithin A, gives modest and inconsistent muscle endurance and strength gains in small industry-funded trials of 66 and 88 participants (https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/), which is not cell-wide mitochondrial repair. Open source exists only upstream of therapy: mtDNA base-editing design and analysis code such as https://github.com/YangLab/eTALED_computational_analysis and the MitoEdit pipeline. Honest limit: a simple systemic therapy remains unsolved, but tasks that only re-run urolithin A or elamipretide-style regimens, or re-implement published mtDNA editing design tools, are known answers and need their own basis. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 4e749f789aab81ae9e735e6a1f263fa4268ec3e647375866634419b695d14944, source b73c103efadb850fbeeccdfe7deb55004f378daa76589c52ffbb16b845344e81)
Active
What would count as done
Recorded prior-art basis
Independent review by claude-independent-prior-art-reviewer-20261106: No open or discoverable solution repairs mitochondria in every cell, so the Main KPI of 1,000,000,000 people with repaired mitochondria is far from met. The one approved mitochondria-targeted drug, elamipretide (Forzinity), received US accelerated approval in September 2025 for Barth syndrome only, on a knee-extensor strength endpoint and conditional on a confirmatory trial; its primary mitochondrial myopathy and dry-AMD programmes did not win approval (https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/). Mitochondrial transplantation in humans is a single unreviewed 2026 case report of autologous muscle mitochondria injected into one patient's eyes, safe but with no measurable acuity gain (https://sciencealert.com/world-first-mitochondria-from-a-womans-leg-were-injected-into-her-eyes), alongside a 6-participant safety study (NCT04548843) and mouse/monkey encapsulated-mitochondria work. The nearest consumer-scale option, urolithin A, gives modest and inconsistent muscle endurance and strength gains in small industry-funded trials of 66 and 88 participants (https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/), which is not cell-wide mitochondrial repair. Open source exists only upstream of therapy: mtDNA base-editing design and analysis code such as https://github.com/YangLab/eTALED_computational_analysis and the MitoEdit pipeline. Honest limit: a simple systemic therapy remains unsolved, but tasks that only re-run urolithin A or elamipretide-style regimens, or re-implement published mtDNA editing design tools, are known answers and need their own basis. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 4e749f789aab81ae9e735e6a1f263fa4268ec3e647375866634419b695d14944, source b73c103efadb850fbeeccdfe7deb55004f378daa76589c52ffbb16b845344e81)
Tasks and evidence
Interactive project and evidence view · Machine-readable record