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  "title": "Repair mitochondria in every cell with a simple therapy",
  "done_when": "",
  "criteria_revision": null,
  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: No open or discoverable solution repairs mitochondria in every cell, so the Main KPI of 1,000,000,000 people with repaired mitochondria is far from met. The one approved mitochondria-targeted drug, elamipretide (Forzinity), received US accelerated approval in September 2025 for Barth syndrome only, on a knee-extensor strength endpoint and conditional on a confirmatory trial; its primary mitochondrial myopathy and dry-AMD programmes did not win approval (https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/). Mitochondrial transplantation in humans is a single unreviewed 2026 case report of autologous muscle mitochondria injected into one patient's eyes, safe but with no measurable acuity gain (https://sciencealert.com/world-first-mitochondria-from-a-womans-leg-were-injected-into-her-eyes), alongside a 6-participant safety study (NCT04548843) and mouse/monkey encapsulated-mitochondria work. The nearest consumer-scale option, urolithin A, gives modest and inconsistent muscle endurance and strength gains in small industry-funded trials of 66 and 88 participants (https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/), which is not cell-wide mitochondrial repair. Open source exists only upstream of therapy: mtDNA base-editing design and analysis code such as https://github.com/YangLab/eTALED_computational_analysis and the MitoEdit pipeline. Honest limit: a simple systemic therapy remains unsolved, but tasks that only re-run urolithin A or elamipretide-style regimens, or re-implement published mtDNA editing design tools, are known answers and need their own basis. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 4e749f789aab81ae9e735e6a1f263fa4268ec3e647375866634419b695d14944, source b73c103efadb850fbeeccdfe7deb55004f378daa76589c52ffbb16b845344e81)",
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    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: No open or discoverable solution repairs mitochondria in every cell, so the Main KPI of 1,000,000,000 people with repaired mitochondria is far from met. The one approved mitochondria-targeted drug, elamipretide (Forzinity), received US accelerated approval in September 2025 for Barth syndrome only, on a knee-extensor strength endpoint and conditional on a confirmatory trial; its primary mitochondrial myopathy and dry-AMD programmes did not win approval (https://www.fightaging.org/archives/2025/10/fda-approval-for-mitochondrial-therapeutic-elamipretide-formerly-ss-31/). Mitochondrial transplantation in humans is a single unreviewed 2026 case report of autologous muscle mitochondria injected into one patient's eyes, safe but with no measurable acuity gain (https://sciencealert.com/world-first-mitochondria-from-a-womans-leg-were-injected-into-her-eyes), alongside a 6-participant safety study (NCT04548843) and mouse/monkey encapsulated-mitochondria work. The nearest consumer-scale option, urolithin A, gives modest and inconsistent muscle endurance and strength gains in small industry-funded trials of 66 and 88 participants (https://pmc.ncbi.nlm.nih.gov/articles/PMC9133463/), which is not cell-wide mitochondrial repair. Open source exists only upstream of therapy: mtDNA base-editing design and analysis code such as https://github.com/YangLab/eTALED_computational_analysis and the MitoEdit pipeline. Honest limit: a simple systemic therapy remains unsolved, but tasks that only re-run urolithin A or elamipretide-style regimens, or re-implement published mtDNA editing design tools, are known answers and need their own basis. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 4e749f789aab81ae9e735e6a1f263fa4268ec3e647375866634419b695d14944, source b73c103efadb850fbeeccdfe7deb55004f378daa76589c52ffbb16b845344e81)",
    "searches": [
      "api.github.com/search/repositories \"repair mitochondria cell simple therapy\" url=https://api.github.com/search/repositories?q=repair%20mitochondria%20cell%20simple%20therapy&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"repair mitochondria cell simple therapy\" url=https://export.arxiv.org/api/query?search_query=all%3Arepair%20AND%20all%3Amitochondria%20AND%20all%3Acell%20AND%20all%3Asimple%20AND%20all%3Atherapy&start=0&max_results=10 sha256=5f16014e02040fa97cf3488b974e9a47f5db24bd277c34ac17c6df85cd230304",
      "api.crossref.org/works \"repair mitochondria cell simple therapy\" url=https://api.crossref.org/works?query=repair%20mitochondria%20cell%20simple%20therapy&rows=10&select=DOI,title sha256=4cc9298d80b9fe91235bb455d0ab0305daa4a4a3b2816288ff13a59d072548ca",
      "api.github.com/search/repositories \"repair mitochondria cell human health longevity\" url=https://api.github.com/search/repositories?q=repair%20mitochondria%20cell%20human%20health%20longevity&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"repair mitochondria cell human health longevity\" url=https://export.arxiv.org/api/query?search_query=all%3Arepair%20AND%20all%3Amitochondria%20AND%20all%3Acell%20AND%20all%3Ahuman%20AND%20all%3Ahealth%20AND%20all%3Alongevity&start=0&max_results=10 sha256=ea656c86390369663c68bb62fba15f2f06858fec0bde5347de7adfe4edb19eb1",
      "api.crossref.org/works \"repair mitochondria cell human health longevity\" url=https://api.crossref.org/works?query=repair%20mitochondria%20cell%20human%20health%20longevity&rows=10&select=DOI,title sha256=5fbdcc42a85f1e10062d31d122b9c79fa7e99ed24511ea1f31a8b97afdd1bf88"
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