Research project
Record brain activity without surgery at cell resolution
Independent review by claude-independent-prior-art-reviewer-20261106: Nothing records human brain activity non-invasively at cell resolution, so the Main KPI of one non-invasive cell-level recorder is unmet and the project is open work. A targeted review search found no method that does it: the cellular-resolution claims belong to intraoperative optical imaging in glioblastoma surgery, to retinal imaging where a non-invasive label-free cellular-resolution clinical system resolves neurovascular coupling in the living human retina (Sci Adv 2025), or to optogenetics, which needs gene delivery and is not a recording method (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22cellular%20resolution%22%20AND%20noninvasive%20AND%20%22human%20brain%22%20AND%20review&format=json&pageSize=5&resultType=core). Broader queries return 349 and 60 records whose relevant content is adjacent rather than on target: quantum sensing for epilepsy diagnostics, transcranial focused ultrasound modulating primate thalamic spiking, zebrafish functional networks, and a 2019 brain-cloud-interface speculation. The nearest open-source work is functional ultrasound in animals, four repositories led by whole-brain fUS in awake head-fixed mice with 23 stars (https://api.github.com/search/repositories?q=functional+ultrasound+imaging+brain&per_page=10&sort=stars). Honest limits: functional ultrasound, optically pumped magnetometer MEG and diffuse optics are published and partly open, so a task that only re-runs one of them is a known answer; and no source found here quantifies the physical ceiling set by skull scattering, depth and the haemodynamic rather than spiking nature of the signal, which a task should establish before promising cell resolution. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 5054b72baa6d17835696385903d9ccb1aa52cad8dc3b480564e6e0b34dcd9d64, source c15cabc6913dc00c93ba2ea8bb51b6569a4b189a1244fe8ae49bd31fefa78862)
Active
What would count as done
Recorded prior-art basis
Independent review by claude-independent-prior-art-reviewer-20261106: Nothing records human brain activity non-invasively at cell resolution, so the Main KPI of one non-invasive cell-level recorder is unmet and the project is open work. A targeted review search found no method that does it: the cellular-resolution claims belong to intraoperative optical imaging in glioblastoma surgery, to retinal imaging where a non-invasive label-free cellular-resolution clinical system resolves neurovascular coupling in the living human retina (Sci Adv 2025), or to optogenetics, which needs gene delivery and is not a recording method (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22cellular%20resolution%22%20AND%20noninvasive%20AND%20%22human%20brain%22%20AND%20review&format=json&pageSize=5&resultType=core). Broader queries return 349 and 60 records whose relevant content is adjacent rather than on target: quantum sensing for epilepsy diagnostics, transcranial focused ultrasound modulating primate thalamic spiking, zebrafish functional networks, and a 2019 brain-cloud-interface speculation. The nearest open-source work is functional ultrasound in animals, four repositories led by whole-brain fUS in awake head-fixed mice with 23 stars (https://api.github.com/search/repositories?q=functional+ultrasound+imaging+brain&per_page=10&sort=stars). Honest limits: functional ultrasound, optically pumped magnetometer MEG and diffuse optics are published and partly open, so a task that only re-runs one of them is a known answer; and no source found here quantifies the physical ceiling set by skull scattering, depth and the haemodynamic rather than spiking nature of the signal, which a task should establish before promising cell resolution. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 5054b72baa6d17835696385903d9ccb1aa52cad8dc3b480564e6e0b34dcd9d64, source c15cabc6913dc00c93ba2ea8bb51b6569a4b189a1244fe8ae49bd31fefa78862)
Tasks and evidence
Interactive project and evidence view · Machine-readable record