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  "source": "independently verified native state; original descriptions retain imported attribution",
  "id": "P-OPP-00248",
  "title": "Build vaccines tailored to each person's immune system",
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  "criteria_revision": null,
  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: Vaccines tailored to each person are real in oncology and absent everywhere else, and nothing approaches the Main KPI of 1,000,000,000 people with tailored vaccines. The furthest-advanced programme is individualised neoantigen mRNA therapy: intismeran autogene (mRNA-4157) is in four phase 3 trials, including 1,089 participants in high-risk melanoma and 868 and 680 in non-small-cell lung cancer, with phase 2 studies in bladder, renal and squamous lung disease (https://clinicaltrials.gov/api/v2/studies?query.intr=mRNA-4157&pageSize=10); nothing is approved. The wider registry picture is small phase 1 studies of per-patient neoantigen peptide, DNA and dendritic-cell vaccines, typically 8 to 64 participants (https://clinicaltrials.gov/api/v2/studies?query.intr=personalized+neoantigen+vaccine&pageSize=15), and the literature on tailoring to an individual immune profile outside cancer is 23 editorial and review records with no product (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22personalized%20vaccine%22%20AND%20%22immune%20profile%22%20AND%20%28HLA%20OR%20immunogenetics%29&format=json&pageSize=8&resultType=lite). The computational half of the problem is openly solved: 45 GitHub repositories implement neoantigen and HLA-aware prediction pipelines, including nextNEOpi (95 stars) and NeoPredPipe (118 stars) (https://api.github.com/search/repositories?q=neoantigen+prediction+pipeline&per_page=10&sort=stars). Honest limit: per-patient epitope selection is a known answer with maintained open-source tools, so a task that re-implements prediction is not new work; the open work is per-person manufacture at hours-to-days turnaround and population cost, immunogenetic coverage outside European-ancestry training data, and any tailored vaccine for infectious disease, where no candidate was found. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 5ac321acd0282f9108bde79cc29eaf8f4262ff01d43df483e30a534a2f3841ba, source e09c12926b2c535a60cead554d96c8ae54e945cb7c920e6752b54cb692380837)",
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    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: Vaccines tailored to each person are real in oncology and absent everywhere else, and nothing approaches the Main KPI of 1,000,000,000 people with tailored vaccines. The furthest-advanced programme is individualised neoantigen mRNA therapy: intismeran autogene (mRNA-4157) is in four phase 3 trials, including 1,089 participants in high-risk melanoma and 868 and 680 in non-small-cell lung cancer, with phase 2 studies in bladder, renal and squamous lung disease (https://clinicaltrials.gov/api/v2/studies?query.intr=mRNA-4157&pageSize=10); nothing is approved. The wider registry picture is small phase 1 studies of per-patient neoantigen peptide, DNA and dendritic-cell vaccines, typically 8 to 64 participants (https://clinicaltrials.gov/api/v2/studies?query.intr=personalized+neoantigen+vaccine&pageSize=15), and the literature on tailoring to an individual immune profile outside cancer is 23 editorial and review records with no product (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22personalized%20vaccine%22%20AND%20%22immune%20profile%22%20AND%20%28HLA%20OR%20immunogenetics%29&format=json&pageSize=8&resultType=lite). The computational half of the problem is openly solved: 45 GitHub repositories implement neoantigen and HLA-aware prediction pipelines, including nextNEOpi (95 stars) and NeoPredPipe (118 stars) (https://api.github.com/search/repositories?q=neoantigen+prediction+pipeline&per_page=10&sort=stars). Honest limit: per-patient epitope selection is a known answer with maintained open-source tools, so a task that re-implements prediction is not new work; the open work is per-person manufacture at hours-to-days turnaround and population cost, immunogenetic coverage outside European-ancestry training data, and any tailored vaccine for infectious disease, where no candidate was found. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 5ac321acd0282f9108bde79cc29eaf8f4262ff01d43df483e30a534a2f3841ba, source e09c12926b2c535a60cead554d96c8ae54e945cb7c920e6752b54cb692380837)",
    "searches": [
      "api.github.com/search/repositories \"vaccines tailored person immune system\" url=https://api.github.com/search/repositories?q=vaccines%20tailored%20person%20immune%20system&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"vaccines tailored person immune system\" url=https://export.arxiv.org/api/query?search_query=all%3Avaccines%20AND%20all%3Atailored%20AND%20all%3Aperson%20AND%20all%3Aimmune%20AND%20all%3Asystem&start=0&max_results=10 sha256=88ba2f37fccb6e95a6b218573a8720477d2d5bcef1400aa18c9efb7482695420",
      "api.crossref.org/works \"vaccines tailored person immune system\" url=https://api.crossref.org/works?query=vaccines%20tailored%20person%20immune%20system&rows=10&select=DOI,title sha256=7f71e71e00f13b3a23c4ad2ac4d6e64aa6f975d377e923087610d1e8a89cff96",
      "api.github.com/search/repositories \"vaccines tailored person infectious disease pandemics\" url=https://api.github.com/search/repositories?q=vaccines%20tailored%20person%20infectious%20disease%20pandemics&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"vaccines tailored person infectious disease pandemics\" url=https://export.arxiv.org/api/query?search_query=all%3Avaccines%20AND%20all%3Atailored%20AND%20all%3Aperson%20AND%20all%3Ainfectious%20AND%20all%3Adisease%20AND%20all%3Apandemics&start=0&max_results=10 sha256=e0c9aba5cbdc6a36a4c3a8f3508d6ff60440a9261d8b8301626cefcf684ad5db",
      "api.crossref.org/works \"vaccines tailored person infectious disease pandemics\" url=https://api.crossref.org/works?query=vaccines%20tailored%20person%20infectious%20disease%20pandemics&rows=10&select=DOI,title sha256=ae153f5b2c02fcae2e22e40fca97679c767800092eafe1869c6c7fd369632ea0"
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