{
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  "state_height": "1645197",
  "app_hash": "5cc1978a6d91211a5d5a4803469b205856a5abdf94159371f0be0872f15ec016",
  "source": "independently verified native state; original descriptions retain imported attribution",
  "id": "P-OPP-00246",
  "title": "Develop needle-free patch vaccines",
  "done_when": "",
  "criteria_revision": null,
  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: No needle-free patch vaccine is licensed anywhere, so the Main KPI of 5,000,000,000 patch doses is far off, but the immunological case is largely made and that must be said plainly. A 2026 Pharmaceutics review reports a phase 1 influenza patch trial with antibody responses non-inferior to the comparator and successful self-application, a phase 1-2 measles-rubella patch trial in Gambian infants with 93 percent measles and 100 percent rubella seroconversion and no related serious adverse events, and dose sparing up to six-fold for influenza, polio and SARS-CoV-2 antigens (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22microarray%20patch%22%20AND%20vaccine%20AND%20%28measles%20OR%20rubella%20OR%20influenza%29%20AND%20trial&format=json&pageSize=3&resultType=core). The registry confirms the stage: the most advanced patch vaccine study is a completed phase 1 high-density microarray patch H7N9 influenza vaccine in 267 adults, with a hepatitis B patch phase 1 in 40 not yet recruiting (https://clinicaltrials.gov/api/v2/studies?query.intr=microarray+patch+vaccine&pageSize=15). That no phase 3 has run is shown by a 2024 paper that still proposes a measles-rubella patch phase 3 framework, among 136 records on patch regulation and implementation research (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22microarray%20patches%22%20AND%20%28%22regulatory%22%20OR%20%22licensure%22%20OR%20%22WHO%22%29%20AND%20vaccine&format=json&pageSize=8&resultType=lite). Open source is absent at the product level: 91 GitHub repositories under microneedle are student simulations, sensors and firmware (https://api.github.com/search/repositories?q=microneedle&per_page=10&sort=stars). Honest limit: patch immunogenicity in phase 1-2 is published prior art and a task that only repeats it is a known answer; the open work is licensure, billion-dose manufacture and cold-chain-free field performance. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 5d1e46c20e8569d61db3a12500d1da6d86c6f64b5c99037944a180e1c05971f2, source 114323c7d3eb01396d2c6138e5c9d07ff17dab1a8780e2fc5e8f1a27e353229d)",
  "lead": "uain158ac8d0debcf01d43164ef14736597da589d8b54",
  "state": "active",
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  "budget_basis": null,
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  "budget_committed": 0,
  "funding_goal": null,
  "prior_art": {
    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: No needle-free patch vaccine is licensed anywhere, so the Main KPI of 5,000,000,000 patch doses is far off, but the immunological case is largely made and that must be said plainly. A 2026 Pharmaceutics review reports a phase 1 influenza patch trial with antibody responses non-inferior to the comparator and successful self-application, a phase 1-2 measles-rubella patch trial in Gambian infants with 93 percent measles and 100 percent rubella seroconversion and no related serious adverse events, and dose sparing up to six-fold for influenza, polio and SARS-CoV-2 antigens (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22microarray%20patch%22%20AND%20vaccine%20AND%20%28measles%20OR%20rubella%20OR%20influenza%29%20AND%20trial&format=json&pageSize=3&resultType=core). The registry confirms the stage: the most advanced patch vaccine study is a completed phase 1 high-density microarray patch H7N9 influenza vaccine in 267 adults, with a hepatitis B patch phase 1 in 40 not yet recruiting (https://clinicaltrials.gov/api/v2/studies?query.intr=microarray+patch+vaccine&pageSize=15). That no phase 3 has run is shown by a 2024 paper that still proposes a measles-rubella patch phase 3 framework, among 136 records on patch regulation and implementation research (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22microarray%20patches%22%20AND%20%28%22regulatory%22%20OR%20%22licensure%22%20OR%20%22WHO%22%29%20AND%20vaccine&format=json&pageSize=8&resultType=lite). Open source is absent at the product level: 91 GitHub repositories under microneedle are student simulations, sensors and firmware (https://api.github.com/search/repositories?q=microneedle&per_page=10&sort=stars). Honest limit: patch immunogenicity in phase 1-2 is published prior art and a task that only repeats it is a known answer; the open work is licensure, billion-dose manufacture and cold-chain-free field performance. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 5d1e46c20e8569d61db3a12500d1da6d86c6f64b5c99037944a180e1c05971f2, source 114323c7d3eb01396d2c6138e5c9d07ff17dab1a8780e2fc5e8f1a27e353229d)",
    "searches": [
      "api.github.com/search/repositories \"develop needle-free patch vaccines\" url=https://api.github.com/search/repositories?q=develop%20needle-free%20patch%20vaccines&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"develop needle-free patch vaccines\" url=https://export.arxiv.org/api/query?search_query=all%3Adevelop%20AND%20all%3Aneedle-free%20AND%20all%3Apatch%20AND%20all%3Avaccines&start=0&max_results=10 sha256=7ba82ec6d5487726dd95fcc3dab17a71e24dfafb83d02c445f7c13d0ce51b2fb",
      "api.crossref.org/works \"develop needle-free patch vaccines\" url=https://api.crossref.org/works?query=develop%20needle-free%20patch%20vaccines&rows=10&select=DOI,title sha256=f0c9c92afe23ac2c4277664acc649d46a55efb67e2cb5086cbd3052bb76cda89",
      "api.github.com/search/repositories \"develop needle-free patch infectious disease pandemics\" url=https://api.github.com/search/repositories?q=develop%20needle-free%20patch%20infectious%20disease%20pandemics&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"develop needle-free patch infectious disease pandemics\" url=https://export.arxiv.org/api/query?search_query=all%3Adevelop%20AND%20all%3Aneedle-free%20AND%20all%3Apatch%20AND%20all%3Ainfectious%20AND%20all%3Adisease%20AND%20all%3Apandemics&start=0&max_results=10 sha256=db8da0ab7e48e959bed8d13a5399cd2343ffec2eb4c6a9bbe358dccac8a72651",
      "api.crossref.org/works \"develop needle-free patch infectious disease pandemics\" url=https://api.crossref.org/works?query=develop%20needle-free%20patch%20infectious%20disease%20pandemics&rows=10&select=DOI,title sha256=68892121dae4c0b3e17a0bfe56a071475be93f6352233b4e11838e2a1ea8b884"
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  "progress": {
    "status": "open",
    "label": "Open",
    "detail": "Derived from finalized native work, tasks, claims and joined instances."
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  "benevolence": {
    "class": "benevolent"
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  "finalized_events": "2017",
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}