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  "source": "independently verified native state; original descriptions retain imported attribution",
  "id": "P-OPP-00243",
  "title": "Make a single shot against all childhood diseases",
  "done_when": "",
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  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: A single shot against all childhood diseases does not exist. The highest valency licensed or trialled childhood combination is hexavalent, six diseases in one injection (diphtheria, tetanus, pertussis, hepatitis B, polio, Hib), seen across registry entries such as LBVD phase 2-3 in 1,186 and 60 infants, DTwP-HepB-IPV-Hib phase 2 in 336 and the V419 programme (https://clinicaltrials.gov/api/v2/studies?query.intr=hexavalent+combination+vaccine&pageSize=15). The 2025-2026 literature is about introducing and valuing hexavalent products, not exceeding them: economics of switching to hexavalent in India, a 2 + 1 schedule in preterm infants, a worldwide survey of combination vaccines in routine programmes and a comparative regulatory study of DTP-containing combinations (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22combination%20vaccine%22%20AND%20%22hexavalent%22%20AND%20children%20AND%20schedule&format=json&pageSize=10&resultType=lite). The WHO routine-immunisation summary tables page gave no count of required vaccines in the fetched text, so the schedule's breadth is stated here only from the combination literature (https://www.who.int/teams/immunization-vaccines-and-biologicals/policies/who-recommendations-for-routine-immunization---summary-tables); it plainly extends past six antigens, including measles, rubella, rotavirus, pneumococcus and HPV, which no single product covers. No open-source candidate or formulation project exists (https://api.github.com/search/repositories?q=vaccine+schedule+combination+antigen+design&per_page=10). Honest limit: hexavalent combination is licensed, widely used and thoroughly published, so a task that only reproduces hexavalent formulation is a known answer; the open work is antigen interference, thermostability and regulatory acceptance beyond six antigens. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 2216284dd1ace27b61a0121e9efdbdc31b79ea5e9bfe0d7915a5b1fc3897b2ef, source 160fff8fcd7e47dfd203c2e922a46e4aba4578f8415ff5d2184929c1cc9c7e34)",
  "lead": "uain158ac8d0debcf01d43164ef14736597da589d8b54",
  "state": "active",
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  "prior_art": {
    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: A single shot against all childhood diseases does not exist. The highest valency licensed or trialled childhood combination is hexavalent, six diseases in one injection (diphtheria, tetanus, pertussis, hepatitis B, polio, Hib), seen across registry entries such as LBVD phase 2-3 in 1,186 and 60 infants, DTwP-HepB-IPV-Hib phase 2 in 336 and the V419 programme (https://clinicaltrials.gov/api/v2/studies?query.intr=hexavalent+combination+vaccine&pageSize=15). The 2025-2026 literature is about introducing and valuing hexavalent products, not exceeding them: economics of switching to hexavalent in India, a 2 + 1 schedule in preterm infants, a worldwide survey of combination vaccines in routine programmes and a comparative regulatory study of DTP-containing combinations (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22combination%20vaccine%22%20AND%20%22hexavalent%22%20AND%20children%20AND%20schedule&format=json&pageSize=10&resultType=lite). The WHO routine-immunisation summary tables page gave no count of required vaccines in the fetched text, so the schedule's breadth is stated here only from the combination literature (https://www.who.int/teams/immunization-vaccines-and-biologicals/policies/who-recommendations-for-routine-immunization---summary-tables); it plainly extends past six antigens, including measles, rubella, rotavirus, pneumococcus and HPV, which no single product covers. No open-source candidate or formulation project exists (https://api.github.com/search/repositories?q=vaccine+schedule+combination+antigen+design&per_page=10). Honest limit: hexavalent combination is licensed, widely used and thoroughly published, so a task that only reproduces hexavalent formulation is a known answer; the open work is antigen interference, thermostability and regulatory acceptance beyond six antigens. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 2216284dd1ace27b61a0121e9efdbdc31b79ea5e9bfe0d7915a5b1fc3897b2ef, source 160fff8fcd7e47dfd203c2e922a46e4aba4578f8415ff5d2184929c1cc9c7e34)",
    "searches": [
      "api.github.com/search/repositories \"single shot childhood diseases\" url=https://api.github.com/search/repositories?q=single%20shot%20childhood%20diseases&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"single shot childhood diseases\" url=https://export.arxiv.org/api/query?search_query=all%3Asingle%20AND%20all%3Ashot%20AND%20all%3Achildhood%20AND%20all%3Adiseases&start=0&max_results=10 sha256=dd6d230563ec7d2bcc2214c54ac85a0cc04e168f730acde46796fcf8f0dde1c5",
      "api.crossref.org/works \"single shot childhood diseases\" url=https://api.crossref.org/works?query=single%20shot%20childhood%20diseases&rows=10&select=DOI,title sha256=601aa7adbf5649a838809eaad3148c7388e5652c96baba82c8d441a32e234967",
      "api.github.com/search/repositories \"single shot childhood infectious disease pandemics\" url=https://api.github.com/search/repositories?q=single%20shot%20childhood%20infectious%20disease%20pandemics&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"single shot childhood infectious disease pandemics\" url=https://export.arxiv.org/api/query?search_query=all%3Asingle%20AND%20all%3Ashot%20AND%20all%3Achildhood%20AND%20all%3Ainfectious%20AND%20all%3Adisease%20AND%20all%3Apandemics&start=0&max_results=10 sha256=5d95f5daefe56f6649300f452782937a5ef99b1a31a15af4d3cd735bb0187ab0",
      "api.crossref.org/works \"single shot childhood infectious disease pandemics\" url=https://api.crossref.org/works?query=single%20shot%20childhood%20infectious%20disease%20pandemics&rows=10&select=DOI,title sha256=981f423d393f65557c22cd76868e3a00311a401eaa43d1a601f58653d1cf2655"
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    "label": "Open",
    "detail": "Derived from finalized native work, tasks, claims and joined instances."
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  "benevolence": {
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  "finalized_events": "2017",
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