{
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  "source": "independently verified native state; original descriptions retain imported attribution",
  "id": "P-OPP-00014",
  "title": "Restore youthful blood by plasma renewal",
  "done_when": "",
  "criteria_revision": null,
  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: Restoring youthful blood by plasma renewal is not achieved at the Main KPI of 100,000,000 people treated, and the evidence that it restores anything youthful is still thin. The two human trials indexed are both 2025 and small: a single-blinded randomised placebo-controlled therapeutic plasma exchange study in healthy adults over 50 reporting multi-omic biological-age markers (Aging Cell, PMID 40424097) and a plasmapheresis efficacy and safety trial (Scientific Reports, PMID 40592961) (https://pubmed.ncbi.nlm.nih.gov/?term=therapeutic+plasma+exchange+biological+age+rejuvenation+randomized). The surrounding 2026 literature is review-level and cautious, including Geroscience on plasma-based strategies with critical perspectives on clinical translation and an Aging Cell review of replacement-based ageing interventions (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22plasma%20exchange%22%20AND%20aging%20AND%20%22biological%20age%22&format=json&pageSize=10&resultType=lite). A registry query for plasma exchange aimed at aging or rejuvenation returned nothing (https://clinicaltrials.gov/api/v2/studies?query.term=therapeutic%20plasma%20exchange%20aging%20rejuvenation&pageSize=15), and no open-source or openly published protocol for rejuvenative apheresis was found (https://api.github.com/search/repositories?q=plasma+exchange+apheresis+rejuvenation&per_page=10). Honest limit: therapeutic plasma exchange is itself an established, widely available apheresis procedure sold today by longevity clinics, so a task that merely administers a plasma-exchange course is a known answer; the open work is whether any regimen durably restores a youthful plasma milieu, which component of plasma matters, and whether the reported biological-age shifts persist rather than fade. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 1c909865030770bb7f3bacebc503ce0f1e75fbd3fa088e30f1d51cf40b702339, source f83021040dcdc655f3997ff05a7e8a92d339ab7052924a300a79e0145923bc8a)",
  "lead": "uain158ac8d0debcf01d43164ef14736597da589d8b54",
  "state": "active",
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  "budget_total": null,
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  "budget_basis": null,
  "budget_unlocked": null,
  "budget_committed": 0,
  "funding_goal": null,
  "prior_art": {
    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: Restoring youthful blood by plasma renewal is not achieved at the Main KPI of 100,000,000 people treated, and the evidence that it restores anything youthful is still thin. The two human trials indexed are both 2025 and small: a single-blinded randomised placebo-controlled therapeutic plasma exchange study in healthy adults over 50 reporting multi-omic biological-age markers (Aging Cell, PMID 40424097) and a plasmapheresis efficacy and safety trial (Scientific Reports, PMID 40592961) (https://pubmed.ncbi.nlm.nih.gov/?term=therapeutic+plasma+exchange+biological+age+rejuvenation+randomized). The surrounding 2026 literature is review-level and cautious, including Geroscience on plasma-based strategies with critical perspectives on clinical translation and an Aging Cell review of replacement-based ageing interventions (https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22plasma%20exchange%22%20AND%20aging%20AND%20%22biological%20age%22&format=json&pageSize=10&resultType=lite). A registry query for plasma exchange aimed at aging or rejuvenation returned nothing (https://clinicaltrials.gov/api/v2/studies?query.term=therapeutic%20plasma%20exchange%20aging%20rejuvenation&pageSize=15), and no open-source or openly published protocol for rejuvenative apheresis was found (https://api.github.com/search/repositories?q=plasma+exchange+apheresis+rejuvenation&per_page=10). Honest limit: therapeutic plasma exchange is itself an established, widely available apheresis procedure sold today by longevity clinics, so a task that merely administers a plasma-exchange course is a known answer; the open work is whether any regimen durably restores a youthful plasma milieu, which component of plasma matters, and whether the reported biological-age shifts persist rather than fade. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 1c909865030770bb7f3bacebc503ce0f1e75fbd3fa088e30f1d51cf40b702339, source f83021040dcdc655f3997ff05a7e8a92d339ab7052924a300a79e0145923bc8a)",
    "searches": [
      "api.github.com/search/repositories \"restore youthful blood plasma renewal\" url=https://api.github.com/search/repositories?q=restore%20youthful%20blood%20plasma%20renewal&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"restore youthful blood plasma renewal\" url=https://export.arxiv.org/api/query?search_query=all%3Arestore%20AND%20all%3Ayouthful%20AND%20all%3Ablood%20AND%20all%3Aplasma%20AND%20all%3Arenewal&start=0&max_results=10 sha256=438b46a326514a4f670092cc1963e9497b830f29c10488c3dfe41e2c93c73ee2",
      "api.crossref.org/works \"restore youthful blood plasma renewal\" url=https://api.crossref.org/works?query=restore%20youthful%20blood%20plasma%20renewal&rows=10&select=DOI,title sha256=8dfe29fad932bcfadca859b1fb334d305c6f7834a108819cdc640e7467cd09b3",
      "api.github.com/search/repositories \"restore youthful blood human health longevity\" url=https://api.github.com/search/repositories?q=restore%20youthful%20blood%20human%20health%20longevity&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"restore youthful blood human health longevity\" url=https://export.arxiv.org/api/query?search_query=all%3Arestore%20AND%20all%3Ayouthful%20AND%20all%3Ablood%20AND%20all%3Ahuman%20AND%20all%3Ahealth%20AND%20all%3Alongevity&start=0&max_results=10 sha256=3444395c941ab9b9d771230109759c9317d932cefeb31d540bf4918ed606e5e3",
      "api.crossref.org/works \"restore youthful blood human health longevity\" url=https://api.crossref.org/works?query=restore%20youthful%20blood%20human%20health%20longevity&rows=10&select=DOI,title sha256=7dabbba2213326821794f6fc9b2039008a34e8f6325f6f9c21fe927e859d7fc5"
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  "progress": {
    "status": "open",
    "label": "Open",
    "detail": "Derived from finalized native work, tasks, claims and joined instances."
  },
  "opened_at": null,
  "benevolence": {
    "class": "benevolent"
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  "finalized_events": "2017",
  "proved": {
    "as_of": "2026-11-15T10:01:31.167Z",
    "age_seconds": 4,
    "heights": {
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    "note": "Every row was proved on the chain. This page shows the chain as it was 4 seconds ago."
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