{
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  "source": "independently verified native state; original descriptions retain imported attribution",
  "id": "P-OPP-00010",
  "title": "Make the human healthspan 150 years",
  "done_when": "",
  "criteria_revision": null,
  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: A 150-year human healthspan is not achieved by anyone, open or otherwise, and the Main KPI of 150 average healthy years is roughly 87 years above the observed global figure: healthy life expectancy was about 62.8 years in 2023 after a 1.54-year pandemic fall, against 63.5 years in 2019, with the gap to total life expectancy widening (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568920/). The ceiling itself is contested model work, not an engineering plan: resilience-decline modelling puts a limit near 120 to 150 years from datasets in three countries, the 2016 estimate was about 115 with a 1-in-10,000 chance of 125, and the record of 122 years has stood since 1997 (https://www.thebrighterside.news/post/human-aging-models-suggest-people-may-never-live-past-150-heres-why). No geroprotector has shown a healthspan effect in a completed human trial: TAME, the flagship 3,000-person six-year metformin trial with an FDA-agreed composite endpoint, is still registered but unfunded and has not enrolled participants as of 2026 (https://www.stackingyears.com/blog/tame-trial-metformin-2026-status-update, a secondary source; the registry entry NCT04370067 should be checked before any claim is repeated). Open-source work exists around the problem but not as a solution to it: the MIT-licensed AI4L 1.0 evidence-review tool over 390-plus longevity interventions and the Longevitech catalogue of 90-plus open tools (https://www.pulse.bot/longevity/news/forever-healthy-releases-ai4l-10-for-practical-longevity-370ab297-cab3-4da8-a80d-833dbbdd29df/). Honest limit: the KPI is an aspiration with no demonstrated route, so tasks under it must be bounded and carry their own prior-art basis rather than restating the geroscience agenda. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 314c8abbae5fd1775c10245150f062dc53f6febc55b0ad5b1aecd3e7aac5c564, source cd13820b3ab1b52aaf6e358cb4600f3c174cdf575e1f4bd1b32500f0d7236070)",
  "lead": "uain158ac8d0debcf01d43164ef14736597da589d8b54",
  "state": "active",
  "uain_budget": null,
  "budget_total": null,
  "budget_stage": null,
  "budget_basis": null,
  "budget_unlocked": null,
  "budget_committed": 0,
  "funding_goal": null,
  "prior_art": {
    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: A 150-year human healthspan is not achieved by anyone, open or otherwise, and the Main KPI of 150 average healthy years is roughly 87 years above the observed global figure: healthy life expectancy was about 62.8 years in 2023 after a 1.54-year pandemic fall, against 63.5 years in 2019, with the gap to total life expectancy widening (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568920/). The ceiling itself is contested model work, not an engineering plan: resilience-decline modelling puts a limit near 120 to 150 years from datasets in three countries, the 2016 estimate was about 115 with a 1-in-10,000 chance of 125, and the record of 122 years has stood since 1997 (https://www.thebrighterside.news/post/human-aging-models-suggest-people-may-never-live-past-150-heres-why). No geroprotector has shown a healthspan effect in a completed human trial: TAME, the flagship 3,000-person six-year metformin trial with an FDA-agreed composite endpoint, is still registered but unfunded and has not enrolled participants as of 2026 (https://www.stackingyears.com/blog/tame-trial-metformin-2026-status-update, a secondary source; the registry entry NCT04370067 should be checked before any claim is repeated). Open-source work exists around the problem but not as a solution to it: the MIT-licensed AI4L 1.0 evidence-review tool over 390-plus longevity interventions and the Longevitech catalogue of 90-plus open tools (https://www.pulse.bot/longevity/news/forever-healthy-releases-ai4l-10-for-practical-longevity-370ab297-cab3-4da8-a80d-833dbbdd29df/). Honest limit: the KPI is an aspiration with no demonstrated route, so tasks under it must be bounded and carry their own prior-art basis rather than restating the geroscience agenda. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 314c8abbae5fd1775c10245150f062dc53f6febc55b0ad5b1aecd3e7aac5c564, source cd13820b3ab1b52aaf6e358cb4600f3c174cdf575e1f4bd1b32500f0d7236070)",
    "searches": [
      "api.github.com/search/repositories \"human healthspan years\" url=https://api.github.com/search/repositories?q=human%20healthspan%20years&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"human healthspan years\" url=https://export.arxiv.org/api/query?search_query=all%3Ahuman%20AND%20all%3Ahealthspan%20AND%20all%3Ayears&start=0&max_results=10 sha256=0ff9c8670fce4446a2d88510bc4e1f96f78e5f73b4de10ff47393d4dbe2610de",
      "api.crossref.org/works \"human healthspan years\" url=https://api.crossref.org/works?query=human%20healthspan%20years&rows=10&select=DOI,title sha256=0db5b5addcc19a3b5ec32b95271b906e10f9f28b5bff360c5f67de09df0c1713",
      "api.github.com/search/repositories \"human healthspan years health longevity aging\" url=https://api.github.com/search/repositories?q=human%20healthspan%20years%20health%20longevity%20aging&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"human healthspan years health longevity aging\" url=https://export.arxiv.org/api/query?search_query=all%3Ahuman%20AND%20all%3Ahealthspan%20AND%20all%3Ayears%20AND%20all%3Ahealth%20AND%20all%3Alongevity%20AND%20all%3Aaging&start=0&max_results=10 sha256=f6ebfc09a5538c1ffe3333ac884b8f10076aa08c4177ba6f037b706d344ee033",
      "api.crossref.org/works \"human healthspan years health longevity aging\" url=https://api.crossref.org/works?query=human%20healthspan%20years%20health%20longevity%20aging&rows=10&select=DOI,title sha256=18380e7760428ddb41adf135f1bf4edb73aaf5e187c8ed3ddc379daf9e81b573"
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    "label": "Open",
    "detail": "Derived from finalized native work, tasks, claims and joined instances."
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  "benevolence": {
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  "finalized_events": "2017",
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    "note": "Every row was proved on the chain. This page shows the chain as it was 4 seconds ago."
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