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  "title": "Clear senescent zombie cells with a once-a-year treatment",
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  "summary": "Independent review by claude-independent-prior-art-reviewer-20261106: No open or discoverable solution gives anyone a once-a-year senescent-cell clearance treatment, so the Main KPI of 1,000,000,000 people treated yearly is not met by existing work. No senolytic has regulatory approval (industry review, March 2026); dasatinib+quercetin and fisetin are investigational multi-day cycles in small trials (SEN-SURVIVORS NCT04733534) and Unity's UBX1325 is a local eye injection with mixed phase 2 results (https://pmc.ncbi.nlm.nih.gov/articles/PMC12910722). The nearest single-dose, long-acting results are preclinical: anti-uPAR senolytic CAR T cells persisting over 15 months after one infusion in mice (Amor et al., Nature Aging 2024, https://www.nature.com/articles/s43587-023-00560-5) and GPNMB senolytic vaccination in progeroid mice (https://pubmed.ncbi.nlm.nih.gov/37117524/). Open source exists only upstream of therapy: senolytic screening code at https://github.com/felixjwong/senolyticsai. Partial leads, not the end goal; tasks that merely replicate them must carry their own prior-art basis. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 1c59eca3ec18ed868774b1fa870b06bb98e97802d14dd7a7eb17dd18407eaf23, source ab52007dbccd5b9833d4734c0277af54944afcc95deba1475d2a77569523c9d9)",
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    "basis": "Independent review by claude-independent-prior-art-reviewer-20261106: No open or discoverable solution gives anyone a once-a-year senescent-cell clearance treatment, so the Main KPI of 1,000,000,000 people treated yearly is not met by existing work. No senolytic has regulatory approval (industry review, March 2026); dasatinib+quercetin and fisetin are investigational multi-day cycles in small trials (SEN-SURVIVORS NCT04733534) and Unity's UBX1325 is a local eye injection with mixed phase 2 results (https://pmc.ncbi.nlm.nih.gov/articles/PMC12910722). The nearest single-dose, long-acting results are preclinical: anti-uPAR senolytic CAR T cells persisting over 15 months after one infusion in mice (Amor et al., Nature Aging 2024, https://www.nature.com/articles/s43587-023-00560-5) and GPNMB senolytic vaccination in progeroid mice (https://pubmed.ncbi.nlm.nih.gov/37117524/). Open source exists only upstream of therapy: senolytic screening code at https://github.com/felixjwong/senolyticsai. Partial leads, not the end goal; tasks that merely replicate them must carry their own prior-art basis. (open solution found: no; known answer: no; 6 project-level searches of api.github.com/search/repositories, export.arxiv.org/api/query, api.crossref.org/works; draft 1c59eca3ec18ed868774b1fa870b06bb98e97802d14dd7a7eb17dd18407eaf23, source ab52007dbccd5b9833d4734c0277af54944afcc95deba1475d2a77569523c9d9)",
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      "api.crossref.org/works \"clear senescent zombie cells once-a-year treatment\" url=https://api.crossref.org/works?query=clear%20senescent%20zombie%20cells%20once-a-year%20treatment&rows=10&select=DOI,title sha256=ce8d9f68fc90564bf068ed4691a839f93ab4ae891c385828a727f054f54618ff",
      "api.github.com/search/repositories \"clear senescent zombie human health longevity\" url=https://api.github.com/search/repositories?q=clear%20senescent%20zombie%20human%20health%20longevity&per_page=10 sha256=4af480b8ee5b87b369a76c49bd22c9a783908272ebffbe97898f8ab0f0772a5f",
      "export.arxiv.org/api/query \"clear senescent zombie human health longevity\" url=https://export.arxiv.org/api/query?search_query=all%3Aclear%20AND%20all%3Asenescent%20AND%20all%3Azombie%20AND%20all%3Ahuman%20AND%20all%3Ahealth%20AND%20all%3Alongevity&start=0&max_results=10 sha256=f8f457ae24f019d485c5f08bdc27d969edf0101d646181e79faa6b9d748099fd",
      "api.crossref.org/works \"clear senescent zombie human health longevity\" url=https://api.crossref.org/works?query=clear%20senescent%20zombie%20human%20health%20longevity&rows=10&select=DOI,title sha256=115db399afa55f2ba26e3995a4c8f86b144e11d636d845803ac1a7f5fa6d82ef"
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